Kisspeptin-54(human) CAS 374683-24-6
Kisspeptin-54, also known as metastin, is a naturally occurring neuropeptide hormone derived from the KISS1 gene in humans. It is one of the longest and most biologically active forms of the kisspeptin family (which also includes Kisspeptin-10, -13, and -14).
- Product Introduction
What Is Kisspeptin-54 (Human) (CAS 374683-24-6)?
Kisspeptin-54, also known as metastin, is a naturally occurring neuropeptide hormone derived from the KISS1 gene in humans. It is one of the longest and most biologically active forms of the kisspeptin family (which also includes Kisspeptin-10, -13, and -14).
Kisspeptin-54 plays a central regulatory role in the hypothalamic–pituitary–gonadal (HPG) axis, acting as a master upstream controller of reproductive hormone release. It exerts its biological effects by binding to the GPR54 (KISS1R) receptor, triggering the secretion of gonadotropin-releasing hormone (GnRH).
Key Biological Functions
- Central regulation of puberty onset
- Control of reproductive hormone secretion
- Regulation of fertility in males and females
- Modulation of gonadal steroid production
- Suppression of tumor metastasis (originally identified as metastasis suppressor)
Mechanism of Action
Activation of KISS1R (GPR54)
Kisspeptin-54 binds to the KISS1 receptor on hypothalamic neurons, initiating intracellular signaling cascades.
Stimulation of GnRH Release
Activation of KISS1R directly stimulates gonadotropin-releasing hormone (GnRH) secretion.
Upregulation of LH & FSH
GnRH release subsequently increases pituitary secretion of:
- Luteinizing hormone (LH)
- Follicle-stimulating hormone (FSH)
These hormones regulate:
Testosterone production
Estrogen synthesis
Spermatogenesis
Ovulation and fertility
Kisspeptin-54 Research Applications
Kisspeptin-54 is widely used in:
- Reproductive endocrinology research
- Fertility and infertility studies
- Hypogonadism models
- Puberty disorders research
- IVF and assisted reproduction research
- Neuroendocrine signaling studies
- Hormonal regulation in men's and women's health
Why Kisspeptin-54 Matters
Vesugen Peptide is commonly used by:
- Athletes and active individuals seeking faster recovery
- People aiming to support vascular and circulatory wellness
- Those interested in healthy aging and cellular protection
- Biohackers and wellness enthusiasts optimizing longevity
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