CB-03-01 CAS 19608-29-8 Powder

 

CB-03-01, also known as Clascoterone, is a novel topical androgen receptor (AR) antagonist developed specifically for skin-targeted androgen-related conditions. Unlike systemic anti-androgens, CB-03-01 acts locally in the skin, where it blocks androgen receptor activation without significantly affecting systemic hormone levels.

This unique profile makes CB-03-01 a next-generation ingredient for research into androgenetic alopecia (AGA), acne vulgaris, and other androgen-driven dermatological conditions.

 

CB-03-01 is a topically active androgen receptor inhibitor designed to block the biological effects of testosterone and dihydrotestosterone (DHT) directly at the skin level.

After topical application, CB-03-01:

• Binds competitively to androgen receptors
• Prevents androgen-driven gene transcription
• Is rapidly metabolized into inactive compounds once absorbed systemically

This design minimizes systemic exposure while maintaining strong local anti-androgen activity.

 

 

Feature	CB-03-01 (Clascoterone)	RU58841	Finasteride
CAS Number	19608-29-8	154992-24-2	98319-26-7
Compound Type	Steroidal anti-androgen	Non-steroidal anti-androgen	5α-reductase inhibitor
Primary Target	Androgen receptor (AR)	Androgen receptor (AR)	5α-reductase (Type II)
Mechanism of Action	Blocks AR locally in skin	Blocks AR in scalp tissue	Reduces DHT production
Effect on DHT Levels	No systemic reduction	No direct reduction	Significant systemic reduction
Systemic Hormonal Impact	Minimal	Potential (dose-dependent)	Yes
Route of Research Use	Topical	Topical	Oral / topical
Designed for Topical Use	Yes (skin-targeted)	Yes (research use)	Not originally
Hair Follicle Protection	Strong	Strong	Moderate–strong
Systemic Side-Effect Risk	Low	Moderate	Higher
Regulatory Background	Dermatology drug	Research compound	Approved drug
Ideal Research Focus	Safe topical anti-androgen	Potent AR blockade	DHT-driven hair loss
Combination Compatibility	Excellent	Good	Excellent

Key Differences Explained

CB-03-01 (Clascoterone)

Skin-targeted androgen receptor inhibitor

Rapidly metabolized systemically

Designed to minimize hormonal side effects

Ideal for long-term topical hair-loss research

RU58841

Powerful androgen receptor antagonist

Strong local effect but less selective

Popular in experimental topical research

Higher systemic exposure risk if misused

Finasteride

Reduces DHT by inhibiting 5α-reductase

Proven clinical effectiveness

Systemic hormonal impact possible

Often combined with topical agents

 

 

Q1: Is CB-03-01 a hormone?
No. It is an androgen receptor antagonist, not a hormone.

Q2: How is CB-03-01 different from Finasteride?
CB-03-01 blocks androgen receptors locally, while Finasteride reduces DHT systemically.

Q3: Is CB-03-01 suitable for topical research?
Yes. It was specifically designed for topical application studies.

Q4: Can it be combined with other hair-loss ingredients?
Yes. It is often studied with minoxidil, peptides, or Wnt-pathway activators.

 

 

Safest topical anti-androgen: CB-03-01

Strongest AR blocker: RU58841

Gold-standard DHT reducer: Finasteride

 

 

A modern solution for advanced dermatology and hair-loss research

 

 

 

 

 

 

 

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